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Absolutely! Let’s dive into the detailed procedures for implementing Duo Multi-Factor Authentication (MFA) with Microsoft 365 and Active Directory. Remember, while I’ll guide you through the steps, it’s always good to have your IT team on hand, especially for the more technical parts.

### Step 1: Check Your Prerequisites
– **For Microsoft 365:** You need global administrator access. Confirm this by logging into your [Microsoft 365 admin center](https://admin.microsoft.com).
– **For Active Directory:** Ensure you have administrative privileges.

### Step 2: Create a Duo Account
1. Go to [Duo’s Signup Page](https://signup.duo.com/).
2. Fill in your details and follow the instructions to set up an account.

### Step 3: Integrate Duo with Active Directory
1. Log into your Duo Admin Panel (you’ll get the link once you sign up).
2. Navigate to **Applications > Protect an Application** and search for “Duo Authentication for Windows Logon.”
3. Click **Protect this Application** to get your integration key, secret key, and API hostname.

For detailed instructions, visit Duo’s guide on [integrating with Active Directory](https://duo.com/docs/rdp).

### Step 4: Set Up Duo with Microsoft 365
1. In the Duo Admin Panel, go to **Applications** and find the Microsoft 365 application.
2. Click **Protect this Application**. Here you’ll get the necessary information to integrate with Microsoft 365.

Detailed instructions can be found in Duo’s [Microsoft 365 integration guide](https://duo.com/docs/o365).

### Step 5: Configure Policies and Groups
1. In the Duo Admin Panel, navigate to **Policies**.
2. Create new policies as needed, specifying authentication requirements and group restrictions.

Duo’s policy guide at [Duo’s Policy Guide](https://duo.com/docs/policy) can be very helpful.

### Step 6: Enroll Users
1. In the Duo Admin Panel, go to **Users**.
2. You can add users manually, import them, or let them self-enroll during their first login attempt.

Check out [Duo’s User Enrollment Guide](https://duo.com/docs/enrolling-users) for step-by-step instructions.

### Step 7: Test Your Setup
1. Attempt to log into Microsoft 365 and a computer on your network using an account enrolled in Duo.
2. Follow the Duo MFA prompts to ensure everything is working correctly.

### Step 8: Train Your Team
1. Organize a training session for your team.
2. Provide them with resources from Duo’s [End-User Guide](https://guide.duo.com/).

### Additional Tips:
– **Document Each Step:** Keep track of your configurations and changes.
– **Communication:** Keep your team informed about the new security measures.

Implementing these steps will significantly enhance your organization’s security posture. Remember, the exact menus and options might slightly vary depending on your specific version of Microsoft 365 and Active Directory. And if you encounter any challenges, Duo’s support and their extensive documentation are fantastic resources. Stay secure and efficient!